BIOptimizers MassZymes Review: What 322,000 HUT of Protease Can and Can’t Do
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MassZymes is BIOptimizers’ flagship digestive enzyme, and it’s built around one number: 322,000 HUT of protease per three capsule serving. Protease is the enzyme family that breaks down protein, which is why lifters on high protein diets keep asking about it.
The recovery angle is indirect. The idea is that better protein digestion means more of what you eat is usable. Here’s what’s in the bottle, what the research does and doesn’t support, and who should skip it.
For more options, read our BIOptimizers Berberine Breakthrough Review and BIOptimizers Microbiome Breakthrough Review.
Key Features
322,000 HUT protease
Per 3 capsule serving, by BIOptimizers’ own label comparison. Far higher than most generic enzyme blends.
Lipase and bromelain
About 10,000 HUT of estimated lipase activity and around 100mg of bromelain per serving.
Vegan and allergen friendly
Labeled vegan, gluten free and dairy free.
365 day guarantee
Return unopened bottles within a year. Opening a second bottle voids the guarantee.
What the Research Says
BIOptimizers cites studies where protease supplements reduced markers of muscle soreness after eccentric exercise, including a 2007 study in the Journal of Strength and Conditioning Research and a 2017 trial in BMJ Open Sport and Exercise Medicine on systemic enzyme therapy. Those studies used their own formulations, not MassZymes itself.
So the fair summary: there’s some evidence that proteolytic enzymes may help with soreness, and there’s a plausible case for digestion support on high protein diets. There isn’t independent clinical proof that MassZymes specifically speeds recovery. The FDA hasn’t evaluated the claims, as with any supplement.
How to Take It
BIOptimizers suggests 1 to 3 capsules before meals, or 3 capsules with your largest meal. It can also be taken on an empty stomach for what they call systemic effects. The capsule contents can be mixed into a drink.
Who Should Skip It
- Anyone pregnant or breastfeeding. BIOptimizers says it isn’t recommended.
- People with gastritis or ulcers.
- Anyone on blood thinning medication, since some enzymes may interact. Talk to your doctor first.
Price Breakdown
- 30 capsules: $18.99
- 120 capsules: $34.99
- 250 capsules: $59.99
Multi bottle bundles and Subscribe and Save cut the per bottle cost further. At 3 capsules a day, the 250 count lasts a bit under three months.
Pros & Cons
What Stands Out
- Very high protease content per serving
- Vegan, gluten free and dairy free
- Flexible sizes from $18.99
- Long 365 day guarantee on unopened bottles
Worth Knowing
- No independent trial on MassZymes itself
- Not for pregnancy, ulcers or blood thinners
- Guarantee voids once a second bottle is opened
- Recovery benefit is indirect
Full Specifications
| Price | $18.99 (30), $34.99 (120), $59.99 (250 capsules) |
| Protease | 322,000 HUT per 3 capsules |
| Lipase | About 10,000 HUT estimated per 3 capsules |
| Bromelain | About 100mg per 3 capsules |
| Diet | Vegan, gluten free, dairy free |
| Suggested use | 1 to 3 capsules before meals |
| Guarantee | 365 days on unopened bottles |
Frequently Asked Questions
Does MassZymes help muscle recovery?
When should I take MassZymes?
Is MassZymes safe?
How much does MassZymes cost?
Final Verdict
BIOptimizers MassZymes is worth trying if you eat a lot of protein and want a high protease enzyme, with 322,000 HUT per serving and a 365 day guarantee on unopened bottles. Just treat any recovery boost as a maybe rather than a promise, and skip it if you’re pregnant, have ulcers or take blood thinners.
Check Price at BIOptimizersRelated Reading
How we put this together: we reviewed BIOptimizers’ published label data, pricing and cited studies, and checked them against the research. We have not taken this supplement ourselves. This isn’t medical advice.
